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MEDICINAL CHEMISTRY

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click on the Red colour title for Notes (from Textbook of Biochemistry vol II by K.Ilango) 1. Modern concept of rational drug design: A brief introduction to Quantitative Structure Activity Relationaship (QSAR) , prodrug, Combinatorial chemistry and Computer aided drug design (CADD) and concept of antisense molecules. A study of the development of the following classes of drugs including SAR, mechanism of action, synthesis of important compounds, chemical nomenclature, brand names of important marketed products and their side effects. 2. Anti-infective agents  a) Local anti-infective agents b) Preservatives c) Antifungal agents d) Urinary tract anti-infectives e) Antitubercular agents f) Antiviral agents and Anti AIDS agents g) Antiprotozoal agents h) Anthelmentics i) Antiscabies and Antipedicular agents 3. Sulphonamides and sulphones  4. Antimalarials   5. Antibiotics   6. Antineoplastic agents 7. Cardiovascular agents  a) Antihypertens...
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PHARMACEUTICAL ANALYSIS

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1. Quality Assurance: a. Introduction, sources of quality variation, control of quality variation. b. Concept of statistical quality control. c. Validation methods- quality of equipment, validation of equipment and validation of analytical  instruments and calibration. d. GLP , ISO 9000 . e. Total quality management , quality review and documentation. f. ICH- international conference for harmonization-guidelines. g. Regulatory control. SOLVED QUESTION BANK  2. Chromatography:          Introduction, history, classification, separation techniques, choice of methods. The following techniques be discussed with relevant examples of pharmaceutical products involving principles and techniques of separation of drugs from excipients.               a. Column Chromatography: Adsorption column chromatography, Operational technique, frontal analysis and elution analysis. Factors affecting column efficiency, applicatio...
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PHARMACOTHERAPEUTICS 2

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Text books (Theory)   Clinical Pharmacy and Therapeutics - Roger and Walker , Churchill Livingstone publication Title of the topic  1. Infectious disease: Guidelines for the rational use of antibiotics and surgical Prophylaxis,  Tuberculosis ,  Meningitis ,  Respiratory tract infections , Gastroenteritis,   Endocarditis ,  Septicemia,  Urinary tract infections ,  Protozoal infection- Malaria, HIV & Opportunistic infections ,  Fungal infections,   Viral infections,  Gonarrhoea and Syphillis   2. Musculoskeletal disorders   Rheumatoid arthritis,   Osteoarthritis ,  Gout,   Spondylitis,  Systemic lupus erythematosus.  3. Renal system   Acute Renal Failure,   Chronic Renal Failure ,  Renal Dialysis ,  Drug induced renal disorders 4. Oncology :  Basic principles of Cancer therapy ,  General introduction to cancer chemotherapeutic age...
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PHARMACEUTICAL JURISPRUDENCE

Text books (Theory)  Mithal , B M. Textbook of Forensic Pharmacy. Calcutta :National; 1988. Title of the topic  1 . Pharmaceutical Legislations – A brief review . 2 . Principle and Significance of professional ethics . Critical study of the code of             Pharmaceutical ethics drafted by PCI.  3. Drugs and Cosmetics Act, 1940,and its rules 1945 .  Objectives, Legal definition,  Study of Schedule’s with reference to Schedule B, C&C1, D, E1, F&F1, F2, F3, FF, G, H, J, K, M, N, P, R, V, W, X, Y.  Sales, Import, labeling and packaging of Drugs And Cosmetics Provisions Relating to Indigenous Systems.  Constitution and Functions of DTAB,DCC,CDL.  Qualification and duties –Govt. analyst and Drugs Inspector.    4. Pharmacy Act –1948.   Objectives Legal Definitions,  General Study, Constitution and Functions of State & Central Council,  Registration & Proc...
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PHARMACEUTICAL FORMULATION

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Text books (Theory)  a. Pharmaceutical dosage forms, Vol, I,II and III by lachman   b. Rowlings Text book of Pharmaceutics   c. Tutorial Pharmacy – Cooper &Gun Topics : 1. Pharmaceutical dosage form concept and classification 2. Tablets :   Formulation of different types of tablets, tablet excipients, granulation techniques quality control and evaluation of tablets. Tablet coating, Type of coating, quality control tests for coated tablet 3. Capsules:   Production and filling of hard gelatin capsules, Raw material for shell, finishing, quality control tests for capsules. Production and filling of soft gelatin capsules, quality control tests for soft gelatin capsules. SOLVED QUESTION BANK 4. Liquid orals:   Formulation and evaluation of suspensions, emulsions and solutions. Stability of these preparations 5. Parenterals : Introduction  Containers used for Parenterals (including official tests) Formulation of...
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PHARMACOLOGY - 2

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1. Pharmacology of Drugs acting on Blood and blood forming agents  a) Anticoagulants  b) Thrombolytics and antiplatelet agents  c) Haemopoietics and plasma expanders 2. Pharmacology of drugs acting on Renal System  a) Diuretics  b) Antidiuretics  3. Chemotherapy a) Introduction b) Sulfonamides and co-trimoxazole c) Penicillins and Cephalosporins d) Tetracyclins and Chloramphenicol e) Macrolides, Aminoglycosides, Polyene & Polypeptide antibiotics f) Quinolines and Fluroquinolines g) Antifungal antibiotics h) Antiviral agents i) Chemotherapy of tuberculosis and leprosy j) Chemotherapy of Malaria k) Chemotherapy of protozoal infections (amoebiasis, Giardiasis) l) Pharmacology of Anthelmintic drugs m) Chemotherapy of cancer (Neoplasms)  4 .  Immunopharmacology     Pharmacology of immunosuppressants and stimulants 5. Principles of Animal toxicology: Acute, sub acute and chronic toxicity 6. The...
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